动物所  |  中国科学院  |  联系我们  
 
学会首页 概况介绍 交流动态 国内学术交流 国际学术交流 海峡两岸学术交流 科研论文
当前位置:首页 > 交流合作 > 科研论文
Debra-Mediated Ci Degradation Controls Tissue Homeostasis in Drosophila Adult Midgut
来源:中国科学院动物研究所 时间:2014-05-22

作者: 李周华*,郭岳琴,韩丽丽,张岩,石来,#X. Huang,林鑫华*

摘要: Adult tissue homeostasis is maintained by resident stem cells and their progeny. However, the underlying mechanisms that control tissue homeostasis are not fully understood. Here, we demonstrate that Debra-mediated Ci degradation is important for intestinal stem cell (ISC) proliferation in Drosophila adult midgut. Debra inhibition leads to increased ISC activity and tissue homeostasis loss, phenocopying defects observed in aging flies. These defects can be suppressed by depleting Ci, suggesting that increased Hedgehog (Hh) signaling contributes to ISC proliferation and tissue homeostasis loss. Consistently, Hh signaling activation causes the same defects, whereas depletion of Hh signaling suppresses these defects. Furthermore, the Hh ligand from multiple sources is involved in ISC proliferation and tissue homeostasis. Finally, we show that the JNK pathway acts downstream of Hh signaling to regulate ISC proliferation. Together, our results provide insights into the mechanisms of stem cell proliferation and tissue homeostasis control.

附件下载:
 
【打印本页】【关闭本页】
  中国动物学会 地址:北京市朝阳区北辰西路1号院5号 邮编:100101
Copyright © 2006-2017 中国科学院动物研究所 备案号:京ICP备05064604号 联系方式:czs@ioz.ac.cn,010-64807051